Which type of side effect may be experienced from typical antipsychotics?

Tardive dyskinesia is a well-documented side effect associated with the long-term use of typical antipsychotics. This condition involves involuntary, repetitive movements affecting various body parts, typically the face, tongue, and limbs. It arises from the drug's mechanism of action, which primarily involves blocking dopamine receptors in the brain. Over time, this receptor blockade can lead to changes in the sensitivity and functioning of the dopamine pathways, resulting in the motor control issues characteristic of tardive dyskinesia.

In contrast, weight loss, while it may occur in some individuals for various reasons, is not a commonly reported side effect of these medications. Euphoria is also not typically associated with typical antipsychotics; they are more often related to drugs with stimulant properties. Insomnia may occur with some medications, but it is not a specific or well-established side effect of typical antipsychotics as tardive dyskinesia is. Thus, among the options provided, tardive dyskinesia is the clear and relevant side effect linked to the use of typical antipsychotics.