EPPP Psychopharmacology Practice Exam

The interaction between monoamine oxidase inhibitors (MAOIs) and tyramine-rich foods can lead to a hypertensive crisis. MAOIs work by inhibiting the enzyme monoamine oxidase, which is responsible for breaking down monoamines, including norepinephrine, dopamine, and serotonin. When individuals on MAOIs consume foods that are high in tyramine (such as aged cheeses, fermented products, and cured meats), tyramine levels can increase significantly.

Under normal circumstances, monoamine oxidase helps to metabolize tyramine. However, with MAOIs, the inhibition of this enzyme leads to an accumulation of tyramine in the body. Tyramine is a sympathomimetic amine that can cause the release of norepinephrine, leading to an excessive increase in blood pressure. This sudden spike can result in symptoms such as a severe headache, tachycardia, sweating, and potentially life-threatening conditions.

Understanding this interaction is crucial for managing patients on MAOIs, as educating them about dietary restrictions can help prevent serious health consequences like a hypertensive crisis.