Which of the following is NOT a first generation antipsychotic?

Clozaril, known generically as clozapine, is classified as a second-generation antipsychotic, which distinguishes it from the first-generation antipsychotics. First-generation antipsychotics, such as Thorazine (chlorpromazine), Haldol (haloperidol), and Prolixin (fluphenazine), primarily target dopamine receptors and are associated with a higher risk of extrapyramidal symptoms.

Clozapine, on the other hand, has a different mechanism of action as it affects both dopamine and serotonin receptors. This dual action contributes to its effectiveness in treating treatment-resistant schizophrenia, as well as its comparatively lower incidence of extrapyramidal side effects, making it a unique option within the antipsychotic spectrum. Understanding this classification helps in recognizing the distinctions between generations of antipsychotics and their respective therapeutic profiles and side effect profiles.