Which of the following is a common tricyclic antidepressant?

Anafranil, or clomipramine, is a common tricyclic antidepressant (TCA) recognized for its efficacy in treating depression as well as obsessive-compulsive disorder (OCD). Tricyclic antidepressants work by inhibiting the reuptake of neurotransmitters such as norepinephrine and serotonin, thereby increasing their availability in the synaptic cleft, which is thought to contribute to their antidepressant effects. Clomipramine is considered particularly effective due to its prominence in research and clinical use for OCD, highlighting its specific therapeutic actions in addition to general antidepressant properties.

In contrast, the other compounds listed belong to different classes of medications and are not classified as TCAs. Phenelzine is a monoamine oxidase inhibitor (MAOI), which works by inhibiting the enzyme that breaks down monoamines, effectively increasing mood-enhancing neurotransmitters. Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI), targeting both serotonin and norepinephrine pathways but differing in mechanism from TCAs. Bupropion is an atypical antidepressant that primarily influences dopamine and norepinephrine systems, lacking the same structure and side effect profile typical of tricyclics. Understanding