Which medication is classified as an atypical antidepressant that primarily acts on dopamine and norepinephrine?

Bupropion is classified as an atypical antidepressant and is unique in its mechanism of action compared to other antidepressants. It primarily acts on the neurotransmitters dopamine and norepinephrine, which distinguishes it from other agents in the class. Specifically, Bupropion inhibits the reuptake of these neurotransmitters, leading to increased levels in the synaptic cleft and enhancing mood and energy levels. This dual action on dopamine and norepinephrine is particularly beneficial for individuals with depression accompanied by fatigue or those who have not responded well to traditional selective serotonin reuptake inhibitors (SSRIs).

In contrast, other options have different primary targets. For example, Fluoxetine, a well-known SSRI, primarily affects serotonin reuptake without significant actions on dopamine. Duloxetine, on the other hand, is a serotonin-norepinephrine reuptake inhibitor (SNRI) and focuses on both serotonin and norepinephrine without the distinct emphasis on dopamine that Bupropion has. Mirtazapine primarily affects serotonin receptors and works on norepinephrine but does not have the same dopamine reuptake inhibition characteristic that sets Bupropion apart. Therefore, Bupropion's specific action on dopamine and norepine