Which antidepressant is often preferred for patients with anxiety disorders?

Sertraline is often preferred for patients with anxiety disorders due to its efficacy in treating both depression and anxiety symptoms. As a selective serotonin reuptake inhibitor (SSRI), sertraline works by increasing the levels of serotonin in the brain, which can help improve mood and reduce anxiety. This dual-action is particularly advantageous, as many patients with anxiety disorders also experience depressive symptoms.

Clinical studies have shown sertraline to be effective in treating various anxiety disorders, including generalized anxiety disorder, panic disorder, and social anxiety disorder. Its favorable side effect profile compared to other classes of antidepressants makes it a common choice among healthcare providers.

In contrast, bupropion, while effective for depression, is generally not the first choice for anxiety disorders due to its stimulating effects that may exacerbate anxiety symptoms in some patients. Amitriptyline, a tricyclic antidepressant, can be effective for anxiety but is often avoided due to its broader side effect profile, including sedation and anticholinergic effects. Fluoxetine is also an SSRI similar to sertraline, but sertraline's specific efficacy in treating anxiety disorders, along with its tolerability, often leads clinicians to prefer it over fluoxetine in this population.