Which antidepressant is noted for increasing dopamine levels?

The correct choice is Wellbutrin (bupropion) because it is specifically known for its action on neurotransmitters, particularly dopamine and norepinephrine. Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI), which means it works by inhibiting the reuptake of both norepinephrine and dopamine, leading to increased levels of these neurotransmitters in the synaptic cleft. This action helps alleviate symptoms of depression and can be particularly beneficial for patients who may also struggle with attention deficit hyperactivity disorder (ADHD) or those who experience sexual side effects from other antidepressants.

Mirtazapine primarily acts on noradrenergic and serotonergic systems, enhancing the release of norepinephrine and serotonin, but it does not specifically target dopamine to the extent that bupropion does. Trazodone, on the other hand, mainly exerts its effects through serotonin modulation and is often used for insomnia due to its sedative properties, rather than being a significant enhancer of dopamine levels. Protriptyline is a tricyclic antidepressant that is more focused on serotonin and norepinephrine, with a weaker influence on dopamine compared to bupropion. Thus