Which antidepressant category is known for being well tolerated with few side effects?

The category of antidepressants that is known for being well tolerated with few side effects is selective serotonin reuptake inhibitors (SSRIs). SSRIs are commonly prescribed due to their favorable side effect profile compared to other classes of antidepressants. They primarily work by increasing the levels of serotonin in the brain, which is a neurotransmitter associated with mood regulation.

Patients generally experience fewer side effects with SSRIs, making them suitable for a wide range of individuals, including those who may be sensitive to medications. Common side effects like gastrointestinal disturbances or mild insomnia tend to be less severe compared to those associated with tricyclic antidepressants, which can cause a range of undesirable effects, including weight gain, sedation, and cardiotoxicity. Furthermore, monoamine-oxidase inhibitors (MAOIs) have dietary restrictions and the potential for dangerous interactions with other medications, leading to a more cumbersome treatment process, while serotonin-norepinephrine reuptake inhibitors (SNRIs) may have a more complex side effect profile than SSRIs.

This overall well-tolerated nature of SSRIs makes them a first-line treatment option for many patients dealing with depression and anxiety disorders, contributing to their popularity in clinical practice.