What term is associated with second generation antipsychotics?

The term "atypical" is commonly associated with second-generation antipsychotics. This classification distinguishes these newer medications from first-generation, or conventional, antipsychotics, which are also referred to as traditional. Atypical antipsychotics are known for their broader mechanism of action and generally reduced risk of extrapyramidal side effects, which are more prevalent with first-generation agents. Examples of atypical antipsychotics include risperidone, olanzapine, and quetiapine. This differentiation reflects how second-generation antipsychotics target a wider range of neurotransmitter systems, including serotonin receptors, in addition to dopamine receptors, leading to improved efficacy for some patients and a different side effect profile compared to their predecessors. Therefore, referring to second-generation antipsychotics as "atypical" helps to highlight these important distinctions in pharmacological properties and clinical application.