What is the most common side effect experienced with SSRIs?

The most common side effect experienced with selective serotonin reuptake inhibitors (SSRIs) is sexual dysfunction. This side effect can manifest in various forms, including decreased libido, delayed ejaculation, anorgasmia, and erectile dysfunction. The prevalence of sexual dysfunction in individuals taking SSRIs can be significant, affecting both men and women. This is primarily due to the way SSRIs increase serotonin levels in the brain, which can interfere with sexual function by suppressing certain pathways involved in sexual arousal and response.

This side effect is critical for clinicians to discuss with patients when prescribing SSRIs, as it can significantly impact a patient's quality of life and their adherence to the medication regimen. Compared to other potential side effects of SSRIs, sexual dysfunction is often reported more frequently in both clinical studies and patient surveys.

While weight loss, blurred vision, and insomnia can also occur with SSRIs, they are less commonly reported. Weight loss is generally not a typical side effect, as SSRIs more frequently cause weight gain over the long term. Blurred vision can occur but is not specifically tied to SSRIs and is less frequently noted by patients. Insomnia can be a side effect as well, but sexual dysfunction remains a more prominent and troublesome issue for many individuals