What is a common adverse effect of the herbal supplement St. John's Wort?

While gastrointestinal upset is indeed an adverse effect of St. John's Wort, it is important to highlight that headaches are also a well-documented side effect associated with this herbal supplement. St. John's Wort is commonly used for its antidepressant properties, but it can lead to various side effects as the body adjusts to or reacts to its active compounds, particularly hypericin and hyperforin.

Gastrointestinal upset can include symptoms such as nausea, diarrhea, or discomfort, which are often reported by individuals taking the supplement. This occurs because the herbal supplement can interact with digestive processes and may influence gut flora or motility. This variability in individual responses further emphasizes the importance of monitoring and understanding each person's reaction to herbal supplements, especially in combination with other medications.

In addition, while skin rashes and sleep disturbances are reported, they are less commonly documented than headaches or gastrointestinal issues, highlighting the complexity of herbal medicine and the importance of being aware of potential side effects. Therefore, gastrointestinal upset is indeed a significant consideration when discussing St. John's Wort and its adverse effects.