What long-term side effect is associated with the use of antipsychotics?

Long-term use of antipsychotic medications is particularly associated with weight gain, which can be a significant concern for patients. This effect is largely due to the alteration of metabolic processes and changes in appetite regulation caused by these medications. Many second-generation antipsychotics, in particular, have been linked to increased appetite and changes in metabolism that contribute to obesity.

Weight gain is not only a cosmetic issue but can lead to further health complications such as diabetes and cardiovascular disease, making it an important factor to monitor in patients on these medications. Managing weight and addressing lifestyle factors becomes essential in the treatment plan for individuals prescribed long-term antipsychotic therapy.

In contrast, while neurological damage could be a theoretical concern, weight gain is a more common and directly observable side effect. Nausea, while it can occur as a side effect, is typically not associated with long-term use. Pulmonary issues are not commonly linked to antipsychotic use, making weight gain the most relevant answer regarding long-term side effects.